Dr. Eric R. Geertsma
Junior Professor
Biocenter N200/1.08
Phone +49-(0)69-798-29255
ax: +49-(0)69-798 29244


Beate Braungart
Administrative assistant
Biocenter N200/1.10
Phone +49-(0)69-798-29238
Fax: +49-(0)69-798 29244


Selected publications

Koch K, Kalusche S, Torres JL, Stanfield RL, Danquah W, Khazanehdari K, von Briesen H, Geertsma ER, Wilson IA, Wernery U, Koch-Nolte F, Ward AB, Dietrich U. 
Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers. 
Sci Rep. 2017 Aug 21;7(1):8390.

Marino J, Holzhüter K, Kuhn B, Geertsma ER. 
Efficient Screening and Optimization of Membrane Protein Production in Escherichia coli
Methods Enzymol. 2017;594:139-164.

Schenck S, Kunz L, Sahlender D, Pardon E, Geertsma ER, Savtchouk I, Suzuki T, Neldner Y, Štefanić S, Steyaert J, Volterra A, Dutzler R. 
Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport. 
Biochemistry. 2017 Aug 1;56(30):3962-3971.

Chang YN, Geertsma ER. 
The novel class of seven transmembrane segment inverted repeat carriers. 
Biol Chem. 2017 Feb 1;398(2):165-174.

Geertsma ER, Chang YN, Shaik FR, Neldner Y, Pardon E, Steyaert J, Dutzler R.
Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family.
Nat Struct Mol Biol. 2015 Oct;22(10):803-8.

Bukowska MA, Hohl M, Geertsma ER, Hürlimann LM, Grütter MG, Seeger MA.
A Transporter Motor Taken Apart: Flexibility in the Nucleotide Binding Domains of a Heterodimeric ABC Exporter.
Biochemistry. 2015 May 19;54(19):3086-99.

Marino J, Hohl M, Seeger MA, Zerbe O, Geertsma ER.
Bicistronic mRNAs to enhance membrane protein overexpression.
J Mol Biol. 2015 Feb 27;427(4):943-54

Ehrnstorfer IA, Geertsma ER, Pardon E, Steyaert J, Dutzler R.
Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport.
Nat Struct Mol Biol. 2014 Nov;21(11):990-6

Malojčić G*, Geertsma ER*, Brozzo MS, Glockshuber R.
Mechanism of the prokaryotic transmembrane disulfide reduction pathway and its in vitro reconstitution from purified components.
Angew Chem Int Ed Engl. 2012 Jul 9;51(28):6900-3

Geertsma ER, Dutzler R.
A versatile and efficient high-throughput cloning tool for structural biology.

Biochemistry. 2011 Apr 19;50(15):3272-8

Mulligan C*, Geertsma ER*, Severi E, Kelly DJ, Poolman B, Thomas GH.
The substrate-binding protein imposes directionality on an electrochemical sodium gradient-driven TRAP transporter.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1778-83

Geertsma ER, Groeneveld M, Slotboom DJ, Poolman B.
Quality control of overexpressed membrane proteins.

Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5722-7

Geertsma ER, Poolman B.
High-throughput cloning and expression in recalcitrant bacteria.

Nat Methods. 2007 Sep;4(9):705-7