Publications 2020


Barth K, Rudolph M, Diederichs T, Prisner TF, Tampé R, Joseph B
Thermodynamic Basis for Conformational Coupling in an ATP-Binding Cassette Exporter.
J Phys Chem Lett 2020 Aug 20; doi:10.1021

Dultz G, Shimakami T, Schneider M, Murai K, Yamane D, Marion A, Zeitler TM, Stross C, Grimm C, Richter RM, Bäumer K, Yi M, Biondi RM, Zeuzem S, Tampé R, Antes I, Lange CM, Welsch C
Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors.
J Biol Chem 2020 Aug 3; doi:10.1074

Khoo KK, Galleano I, Gasparri F, Wieneke R, Harms H, Poulsen MH, Chua HC, Wulf M, Tampé R, Pless SA
Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing.
Nat Commun 2020;s41467 doi: 10.1038

Thomas C, Tampé R
Structural and mechanistic principles of ABC transporters.
Annu Rev Biochem, in press; doi:10.1146

Stefan E, Hofmann S, Tampé R
A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC Transporter.
eLife 2020;9:e55943 doi: 10.7554

Brüchert S, Joest EF, Gatterdam K, Tampé R
Ultrafast in-gel detection by fluorescent super-chelator probes with HisQuick-PAGE.
CommunBiol2020 doi: 10.1038/s42003-020-0852-1

Mavridis G, Arya R, Domnick A, Zoidakis J, Makridakis M, Vlahou A, Mpakali A, Lelis A, Georgiadis D, Tampé R, Papakyriakou A, Stern LJ, Stratikos E
A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by ER aminopeptidase 1.
J Biol Chem.2020 MAR 17:jbc.RA120.012976 doi: 10.1074/jbc.RA120.012976

Sagert L, Hennig F, Thomas C, Tampé R
A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor.
Elife.2020 Mar 13;9:e55326 doi: 10.7554

Nürenberg-Goloub E, Kratzat H, Heinemann H, Heuer A, Kötter P, Berninghausen O, Becker T, Tampé R, Beckmann R
Molecular analysis of the ribosome recycling factor ABCE1 bound to the 30S post-splitting complex.
EMBO J.2020 Feb 17:e103788 doi: 10.15252

Trowitzsch S, Tampé R
Multifunctional chaperone and quality control complexes in adaptive immunity. 
Annu Rev Biophys 2020 Jan 31 doi: 10.1146


Publications 2019

Diederichs T, Pugh G, Dorey A, Xing Y, Burns JR, Nguyen QH,Tornow M,Tampé R, Howorka S.
Synthetic protein-conductive membrane nanopores built with DNA.
Nat Commun 10, 5018 (2019) doi:10.1038/s41467-019-12639-y

Nürenberg-Goloub E, Tampé R.
Ribosome recycling in mRNA translation, quality control, and homeostasis.
Biol Chem. 2019 Oct 1. pii: /j/bchm.just-accepted/hsz-2019-0279/hsz-2019-0279.xml. doi: 10.1515/hsz-2019-0279. [Epub ahead of print]

Bock C, Zollmann T, Lindt KA, Tampé R, Abele R.
Peptide translocation by the lysosomal ABC transporter TAPL is regulated by coupling efficiency and activation energy.
Sci Rep. 2019 Aug 15;9(1):11884. doi: 10.1038/s41598-019-48343-6.

Hofmann S, Januliene D, Mehdipour AR, Thomas C, Stefan E, Brüchert S, Kuhn BT, Geertsma ER, Hummer G, Tampé R, Moeller A.
Conformation space of a heterodimeric ABC exporter under turnover conditions.
Nature. 2019 Jul 17. doi: 10.1038/s41586-019-1391-0. [Epub ahead of print]

Gouridis G, Hetzert B, Kiosze-Becker K, de Boer M, Heinemann H, Nürenberg-Goloub E, Cordes T, Tampé R.
ABCE1 Controls Ribosome Recycling by an Asymmetric Dynamic Conformational Equilibrium.
Cell Rep. 2019 Jul 16;28(3):723-734.e6. doi: 10.1016/j.celrep.2019.06.052.

Baldering TN, Dietz MS, Gatterdam K, Karathanasis C, Wieneke R, Tampé R, Heilemann M.
Synthetic and genetic dimers as quantification ruler for single-molecule counting with PALM.
Mol Biol Cell. 2019 Jun 1;30(12):1369-1376. doi: 10.1091/mbc.E18-10-0661. Epub 2019 Apr 10.

Wieneke R, Tampé R.
Multivalent Chelators for In Vivo Protein Labeling.
Angew Chem Int Ed Engl. 2019 Jun 17;58(25):8278-8290. doi: 10.1002/anie.201811293. Epub 2019 Mar 27.

Graab P, Bock C, Weiss K, Hirth A, Koller N, Braner M, Jung J, Loehr F, Tampé R, Behrends C, Abele R.
Lysosomal targeting of the ABC transporter TAPL is determined by membrane localized charged residues.
J Biol Chem. 2019 Mar 15. pii: jbc.RA118.007071. doi: 10.1074/jbc.RA118.007071.

Döring M, Blees H, Koller N, Tischer-Zimmermann S, Müsken M, Henrich F, Becker J, Grabski E, Wang J, Janssen H, Zuschratter W, Neefjes J, Klawonn F, Eiz-Vesper B, Tampé R, Kalinke U.
Modulation of TAP-dependent antigen compartmentalization during human monocyte-to-DC differentiation.
Blood Adv. 2019 Mar 26;3(6):839-850. doi:10.1182/bloodadvances.2018027268.

Thomas C,Tampé R.
MHC I chaperone complexes shaping immunity
Curr Opin Immunol. 2019 Jun;58:9-15. doi: 10.1016/j.coi.2019.01.001. Epub 2019 Feb 14.

Braner M, Koller N, Knauer J, Herbring V, Hank S, Wieneke R, Tampé R. 
Optical control of the antigen translocation by synthetic photo-conditional viral inhibitors.
Chem Sci. 2018 Dec 17;10(7):2001-2005. doi: 10.1039/c8sc04863k. eCollection 2019 Feb 21.

Gerovac M, Tampé R.
Control of mRNA Translation by Versatile ATP-Driven Machines.
Trends Biochem Sci. 2019 Feb;44(2):167-180. doi: 10.1016/j.tibs.2018.11.003. Epub 2018 Dec 7.

Publications 2018

Bock C, Löhr F, Tumulka F, Reichel K, Würz J, Hummer G, Schäfer L, Tampé R, Joseph B, Bernhard F, Dötsch V,  Abele R.
Structural and functional insights into the interaction and targeting hub TMD0 of the polypeptide transporter TAPL
Sci Rep. 2018 Oct 23;8(1):15662. doi: 10.1038/s41598-018-33841-w.

Klein A, Hank S, Raulf A, Joest EF, Tissen F, Heilemann M, Wieneke R, Tampé R.
Live-cell labeling of endogenous proteins with nanometer precision by transduced nanobodies
Chem Sci. 2018 Aug 20;9(40):7835-7842. doi: 10.1039/c8sc02910e. eCollection 2018 Oct 28.

Glembockyte V, Wieneke R, Gatterdam K, Gidi Y, Tampé R, Cosa G.
Tris -N-Nitrilotriacetic Acid Fluorophore as a Self-Healing Dye for Single-Molecule Fluorescence Imaging.
J Am Chem Soc. 2018 Sep 5;140(35):11006-11012. doi: 10.1021/jacs.8b04681. Epub 2018 Aug 23.

Trowitzsch S, Tampé R.
ABC Transporters in Dynamic Macromolecular Assemblies.
J Mol Biol. 2018 Oct 26;430(22):4481-4495. doi: 10.1016/j.jmb.2018.07.028. Epub 2018 Aug 5.

Brzozowska E, Leśniewski A, Sęk S, Wieneke R, Tampé R, Górska S, Jönsson-Niedziółka M, Niedziółka-Jönsson J.
Interactions of bacteriophage T4 adhesin with selected lipopolysaccharides studied using atomic force microscopy.
Sci Rep. 2018 Jul 19;8(1):10935. doi: 10.1038/s41598-018-29383-w.

Elina Nürenberg-Goloub, Holger Heinemann, Milan Gerovac, Robert Tampé. 
Ribosome recycling is coordinated by processive events in two asymmetric ATP sites of ABCE1
Life Sci Alliance. 2018 Jun 14;1(3). pii: e201800095. doi: 10.26508/lsa.201800095.

Gatterdam K, Joest EF, Gatterdam V, Tampé R.
The Scaffold design of trivalent chelator heads dictates high-affinity and stable His-tagged protein labeling in vitro and in cellulo.
Angew Chem Int Ed Engl. 2018 Sep 17;57(38):12395-12399. doi: 10.1002/anie.201802746. Epub 2018 Jun 26.

Abele R and Tampé R
Moving the Cellular Peptidome by Transporters
Front Cell Dev Biol. 2018 Apr 30;6:43. doi: 10.3389/fcell.2018.00043. eCollection 2018.

Diederichs T, Nguyen QH, Urban M, Tampé R, Tornow M.
Transparent Nanopore Cavity Arrays Enable Highly Parallelized Optical Studies of Single Membrane Proteins on Chip.
Nano Lett. 2018 Jun 13;18(6):3901-3910. doi: 10.1021/acs.nanolett.8b01252. Epub 2018 May 14.

Thomas C, Tampé R.
Multifaceted structures and mechanisms of ABC transport systems in health and disease
Curr Opin Struct Biol. 2018 Aug;51:116-128. doi: 10.1016/ Epub 2018 Apr 9.

Posch S, Obser T, König G, Schneppenheim R, Tampé R, Hinterdorfer P.
Interaction of von Willebrand factor domains with collagen investigated by single molecule force spectroscopy.
J Chem Phys. 2018 Mar 28;148(12):123310. doi: 10.1063/1.5007313.

Venkataramani V, Kardorff M, Herrmannsdörfer F, Wieneke R, Klein A, Tampé R, Heilemann M Kuner T.
Enhanced labeling density and whole-cell 3D dSTORM imaging by repetitive labeling of target proteins.
Sci Rep. 2018 Apr 3;8(1):5507. doi: 10.1038/s41598-018-23818-0.

Gatterdam K, Joest EF, Dietz MS, Heilemann M, Tampé R.
Super-chelators for advanced protein labeling in living cells

Angew Chem Int Ed Engl. 2018 May 14;57(20):5620-5625. doi: 10.1002/anie.201800827. Epub 2018 Apr 14.

Barth K, Hank S, Spindler PE, Prisner TF, Tampé R, Joseph B.
Conformational Coupling and trans-Inhibition in the Human Antigen Transporter Ortholog TmrAB Resolved with Dipolar EPR Spectroscopy.
J Am Chem Soc. 2018 Jan 30. doi: 10.1021/jacs.7b12409. [Epub ahead of print]

Bartelt SM , Chervyachkova E , Steinkühler J , Ricken J , Wieneke R , Tampé R , Dimova R , Wegner SV .
Dynamic blue light-switchable protein patterns on giant unilamellar vesicles.
Chem Commun (Camb). 2018 Jan 23;54(8):948-951. doi: 10.1039/c7cc08758f.