Group Members

Dr. Alexander Gottschalk
Professor & Group Leader     
phone +49-(0)69-798-42518fax +49-(0)69-798-763-42518
a.gottschalk@em.uni-frankfurt.de

Dr. Jana Liewald        
Postdoctoral Fellow
phone +49-(0)69-798-42513
j.liewald@biochem.uni-frankfurt.de

Dr. Christina Schüler      
Postdoctoral Fellow
phone +49-(0)69-798-42520
c.schueler@em.uni-frankfurt.de

Dr. Holger Dill    
Postdoctoral Fellow
phone +49-(0)69-798-42519
dill@biochem.uni-frankfurt.de

Dr. Jiajie Shao    
Postdoctoral Fellow
phone +49-(0)69-798-42520
shao@em.uni-frankfurt.de

Dr. Ichiro Aoki    
Postdoctoral Fellow
phone +49-(0)69-798-42520
Aoki@bio.uni-frankfurt.de

Barbara Jánosi
PhD Student    
phone +49-(0)69-798-42519
Janosi@em.uni-frankfurt.de

Thilo Henß      
PhD Student
phone +49-(0)69-798-42519
Henss@biochem.uni-frankfurt.de

Jonas Weil    
PhD Student
phone +49-(0)69-798-42713
weil@biochem.uni-frankfurt.de

Marcial Engel    
PhD Student
phone +49-(0)69-798-42713
marcial.engel@biochem.uni-frankfurt.de

Frank Becker    
PhD Student
phone +49-(0)69-798-42519
fr.becker@em.uni-frankfurt.de

Maximilian Bach    
PhD Student
phone +49-(0)69-798-42519
Bach@bpc.uni-frankfurt.de

Amelie Bergs  
Phd Student
phone +49-(0)69-798-42713
bergs@biochem.uni-frankfurt.de

Dennis Vettkötter     
PhD Student
phone +49-(0)69-798-42519
vettkoetter@biochem.uni-frankfurt.de


GEGEN FREMDENFEINDLICHKEIT !

AGAINST XENOPHOBIA !


@ Buchmann Institute for Molecular Life Sciences
Max von Laue Strasse 15, D-60438 Frankfurt / Germany
Ph: ++49-69-798 42518; Fax: ++49-69-798 763 42518

 

For other website, see here: BMLS

We work in three main areas, in the context of molecular, cellular and behavioral neurobiology: 1) How neuronal activity evokes and modulates behavior, 2) mechanisms of chemical synaptic transmission, and 3) we are developing methods, particularly in optogenetics. Our model animal is the soil nematode Caenorhabditis elegans. We recently began to applying our methods in also zebrafish larvae.

1) To analyze neuronal networks and their involvement in behavior, we express optogenetic tools in defined neurons, or specifically photoactivate defined neurons, to evoke, inhibit or modulate the behavior controlled by these cells. This allows analyzing cell-autonomous function of genes needed in that cell.

2) Components of the machineries that mediate synaptic transmission, both on the pre-synaptic side (e.g. synaptic vesicle proteins), and on the post-synaptic side (e.g. proteins associated with neurotransmitter receptors) are analyzed by a combination of optogenetics, genetics, cell biology, electrophysiology and electron microscopy.

3) Optogenetic tools that we developed or implemented include rhodopsin-based actuators and inhibitors, light-driven enzymes for 2nd messengers, photoactivated degrons and clostridial neurotoxins, and genetically encoded fluorescent indicators for Ca2+, cGMP and membrane voltage.