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Institute of Biochemistry
Publications 2022

Winter C, Domnick A, Cernova D, Tampé R
Semisynthetic viral inhibitor for light control of the MHC I peptide loading complex.
Angew Chem Int Ed Engl. (2022)

Sánchez MF, Dietz MS, Müller U, Weghuber J, Gatterdam K, Wieneke R, Heilemann M, Lanzerstofer P, Tampé R
Dynamic in situ confinement triggers ligand-free neuropeptide receptor signaling.
Nano Lett. (2022)

Sánchez MF, Tampé R
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm.
TIBS (2022) doi:10.1016

Müller IK, Winter C, Thomas C, Spaapen RM, Trowitzsch S, Tampé R (2022)
Structure of an MHC I-tapasin-ERp57 editing complex defines chaperone promiscuity.
Nat Commun, 13: 5383

Sekulovski S, Susac L, Stelzl L, Tampé R, Trowitzsch S (2022)
Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN.
BioRxiv, 506465v1

Chan JF-W, Oh YJ, Yuan S, Chu H, Yeung M-L, Canena D, Chan CC-S, Poon VK-M, Chan CC-Y, Zhang AJ, Cai J-P, Ye Z-W, Wen L, Yuen TT-T, Kenn Chik KK-H, Shuai H, Wang Y, Yuxin Hou Y, Luo C, Chan W-M, Sit K-Y, Au W-K, Lengendre M, Zhu R, Hain L, Seferovic H, Tampé R, To KK-W, Chan K-H, Thomas DG, Klausberger M, Stadlmann J, Penninger JM, Oostenbrink O, Hinterdorfer P, Yuen K-Y, Markovitz D (2022)
A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo.
Cell Rep Med, 2022 Sep29:100774

Susac L, Yuong MT, Thomas C, von Bülow S, O'Brien-Ball C, Santos AM, Fernandes RA, Hummer G, Tampé R*, Davis SJ* (2022)
Structure of a fully assembled tumor-specific T-cell receptor ligated by pMHC.
Cell, 2022 Aug 18
*corresponding authors

Domnick A, Winter C, Susac L, Hennecke L, Hensen M, Zitzmann N, Trowitzsch S, Thomas C, Tampé R (2022)
Molecular basis of MHC I quality control in the peptide loading complex.
Nat Commun, 2022 Aug 10;13(1):4701.

Koller N, Höllthaler P, Barends M, Döring M, Spahn C, Duran V, Costa B, Becker J, Heilemann M, Kalinke U, Tampé R (2022)
Nanoscale organization of the MHC I peptide loading complex in human dendritic cells.
Cell Mol Life Sci, 2022 Aug 10;79(9):477.
doi: 10.007/s00018-022-04472-2

Joest EF, Winter C, Wesalo JS, Deiters A, Tampé R (2022)
Efficient Amber Suppression via Ribosomal Skipping for In Situ Synthesis of Photoconditional Nanobodies.
ACS Synth. Biol. 2022, 11, 1466-1476
Cover Page

Sánchez MF, Dietz MS, Müller U, Weghuber J, Gatterdam K, Wieneke R, Heilemann M, Lanzerstorfer P, Tampé R (2021)
Dynamic in situ confinement triggers ligand-free neuropeptide receptor signaling.
BioRxiv 472742


Krüger H, Asido M, Wachtveitl J, Tampé R, Wieneke R (2022)
Sensitizer-enhanced two-photon patterning of biomolecules in photoinstructive hydrogels.
Commun Materials, 3, 9

Sethumadhavan S, Barth M, Spaapen RM, Schmidt C, Trowitzsch S, Tampé R (2022)
Viral immune evasins impact antigen presentation by allele-specific trapping of MHC I at the peptide-loading complex.
Sci Rep 12, 1516.

Publications 2021


Diederichs T, Ahmad K, Burns JR, Nguyen QH, Siwy ZS, Tornow M, Coveney PV, Tampé R, Howorka S
Principles of small molecule transport through synthetic nanopores.
ACS Nano 2021, in press

Stefan E, Obexer R, Hofmann S, Vu Huu K, Huang Y, Morgner N, Suga H, Tampé R
De-novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition.
eLife 10 2021, e67732; doi:10.7554/eLife.67732

Joest EF, Winter C, Wesalo JS, Deiters A, Tampé R
Light-guided intrabodies for on-demand in-situ target recognition in human cells.
Chem Science 2021, 12,5787-95; doi:10.1039/D1SC01331A

Durán V, Grabski E, Hozsa C, Becker J, Yasar H, Costa B, Koller N, Lueder Y, Wiegmann B, Brandes G, Kaever V, Lehr CM, Tampé R, Förster R, Bosnjak B, Furch M, Graalmann T, Kalinke U
Fucosylated lipid nanocarriers loaded with antibiotics efficiently inhibit mycobacterial propagation in human myelid cells.
J Controlled Release 334. 2021, 201-22; doi:10.1016/j.conrel.2021Joest.04012

Barbet G, Nair-Gupta P, Schotsaert M, Yeung ST, Moretti J, Seyffer F, Metreveli G, Gardner T, Choi A, Tortorella D, Tampé R, Khanna KM, Garcia-Sastre A, Blander JM
TAP dysfunction in dendritic cells enables noncanonical cross-penetration for T cell priming.
Nat Immunol. 2021 Mar 31; doi:10.1038/s41590-021-00903-7.

Brunnberg J, Herbring V, Günther Castillo E, Krüger H, Wieneke R, Tampé R
Light control of the peptide-loading complex synchronizes antigen translocation and MHC trafficking.
Commun Biol.2021.doi: 10.1038/s42003-021-01890-z

Herrmann J, Tampé R
Die Biochemie-Studiengänge bekommen mehr Sichtbarkeit.


Diederichs T, Tampé R
Single cell-like systems reveal active unidirectional and light-controlled transport by nanomachineries.
ACS Nano.2021. doi: 10.1021/acsnano.0c10139. Online ahead of print.

Thomas C, Tampé R
MHC I assembly and peptide editing - chaperones, clients, and molecular plasticity in immunity.
Current Opinion in Immunology. 2021, 70:48-56 (PDF)

Sánchez MF, Els-Heindl S, Beck-Sickinger AG, Wieneke R, Tampé R
Photo-induced receptor confinement drives ligand-independent GPCR signaling.
Science. 2021 Feb 25: eabb7657. doi: 10.1126/science.abb7657. Online ahead of print. PMID: 33632896

deWaard AA, Verkerk T, Jongsma MLM, Hoefakker K, Sethumadhavan S, Gerke C, Bliss S, Kong X, Janssen GMC, deRu AH, Claas FHJ, Mulder A, Tampé R, vanVeelen PA, Halenius A, Spaapen RM
PAKC: A novel Panel of HLA class I Antigen presentation machinery Knockout Cells from the same genetic origin
2020,Eur J Immunol., doi: 10.1002/eji.202048599