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Institute of Biochemistry
Publications

Silberberg JM*, Stock C*, Hielkema L*, Corey RA, Rheinberger J, Wunnicke D, Dubach VRA, Stansfeld PJ, Hänelt I#, Paulino C#  (2022)
Inhibited KdpFABC transitions into an E1 off-cycle state.
eLife 11:e80988

Silberberg JM*, Corey RA*, Hielkema L*, Stock C, Stansfeld PJ#, Paulino C#, Hänelt I# (2021)
Deciphering ion transport and ATPase coupling in the intersubunit tunnel of KdpFABC.
Nat Comm 12:5098

Stautz J*, Hellmich Y*, Fuss MF*, Silberberg JM*, Devlin JR, Stockbridge RB#, Hänelt I# (2021)
Molecular mechanisms for bacterial potassium homeostasis.
J Mol Biol 433:166968

Tascon I*, Sousa J*, Corey RA, Mills DJ, Griwatz D, Aumüller N, Mikusevic V, Stansfeld PJ, Vonck J#, Hänelt I# (2020)
Structural basis of proton-coupled potassium transport in the KUP family.
Nat Comm 11:626

Krüger L, Herzberg C, Warneke R, Poehlein A, Stautz J, Weiß M, Daniel R, Hänelt I, Stülke J# (2020)
Two ways to convert a low-affinity potassium channel to high affinity: Control of Bacillus subtilis KtrCD by glutamate.
J Bacteriol 202:e00138-20

Stock C, Hänelt I# (2020)
Membrane Protein Solubilization and Quality Control: An Example of a Primary Active Transporter.
Methods Mol Biol 2127:93-103

Ballweg S, Sezgin E, Doktorova M, Covino R, Reinhard J, Wunnicke D, Hänelt I, Levental I, Hummer G, Ernst R# (2020)
Regulation of lipid saturation without sensing membrane fluidity.
Nat Commun 11:756

Mikusevic V, Schrecker M, Patiño-Ruiz M, Fendler K, Hänelt I# (2019)
A channel profile report of the unusual K+ channel KtrB.
J Gen Physiol 151:1357-1368

Gundlach J, Krüger L, Herzberg C, Turdiev A, Poehlei A, Tascón I, Weiß M, Hertel D, Daniel R, Hänelt I, Lee VT, Stülke J# (2019)
Sustained sensing in potassium homeostasis: Cyclic di-AMP controls potassium uptake by KimA at the levels of expression and activity.
J Biol Chem 294:9605-9614

Stock C*, Hielkema L*, Tascon I*, Wunnicke D, Oostergetel G, Azkargorta M, Paulino C#, Hänelt I# (2018)
Cryo-EM structures of KdpFABC suggest a K+ transport mechanism via two inter-subunit half-channels.
Nat Comm 9:4971

Hellwig N, Peetz O, Ahdash Z, Tascón I, Booth PJ, Mikusevic V, Diskowski M, Politis A, Hellmich Y, Hänelt I, Reading E, Morgner N# (2018)
Native mass spectrometry goes more native: investigation of membrane protein complexes directly from SMALPs.
Chem Comm 54:13702-13705

Halbleib K, Pesek K, Covino R, Hofbauer HF, Wunnicke D, Hänelt I, Hummer G, Ernst R# (2017)
Activation of the unfolded protein response by lipid bilayer stress.
Mol Cell 67:673-684

Diskowski M, Mehdipour AR, Wunnicke D, Mills D, Mikusevic V, Bärland N, Hoffmann J, Morgner N, Steinhoff HJ, Hummer G, Vonck J#, Hänelt I# (2017)
Helical jackknives control the gates of the double-pore K+ uptake system KtrAB.
eLife 6:e24303

Wunnicke D, Hänelt I# (2017)
The synergetic effects of combining structural biology and EPR spectroscopy.
Crystals 7:117

Diskowski M*, Mikusevic V*, Stock, C*, Hänelt I# (2015)
Functional diversity of the superfamily of K+ transporters to meet various requirements.
Biol Chem 396:1003-1014

Prior independence

Hänelt I*, Jensen S*, Wunnicke D, Slotboom DJ# (2015)
Low affinity and slow Na+ binding precedes high affinity aspartate binding in GltPh.
J Biol Chem 290:15962-15972

Shiyan A, Thompson M, Köcher S, Tausendschön M, Santos H, Hänelt I, Müller V# (2014)
Glutamine synthetase 2 is not essential for biosynthesis of compatible solutes in Halobacillus halophilus.
Front Microbiol, doi: 10.3389/fmicb.2014.00168

Erkens GB, Hänelt I, Goudsmits JMH, Slotboom DJ#, van Oijen AM# (2013)
Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters.
Nature 502:119-123

Jensen S, Guskov A, Rempel S, Hänelt I, Slotboom DJ# (2013)
Crystal structure of a substrate-free aspartate transporter.
Nat Struct Mol Biol 20:1224-1226

Majsnerowska M*, Hänelt I*, Wunnicke D*, Schäfer LV, Steinhoff HJ, Slotboom DJ# (2013)
Substrate-induced conformational changes in the S-component ThiT from an energy coupling factor transporter.
Structure 21:861-867

Hänelt I, Wunnicke D, Bordignon E, Steinhoff HJ, Slotboom DJ#(2013)
Conformational heterogeneity of the aspartate transporter Glt(Ph).
Nat Struct Mol Biol, 20: 210-214

Pade N, Köcher S, Roeßler M, Hänelt I, Müller V# (2013)
Bioenergetics of the moderately halophilic bacterium Halobacillus halophilus: Composition and regulation of the respiratory chain.
Appl Environ Microbiol 79: 3839-3846

Hänelt I, Müller V# (2013)
Molecular mechanisms of adaptation of the moderately halophilic bacterium Halobacillis halophilus to its environment.
Life 3:234-43

Hänelt I#, Tholema N, Kröning N, Vor der Brüggen M, Wunnicke D, Bakker EP (2011)
KtrB, a member of the superfamily of K+ transporters.
Eur J Cell Biol 90:696-704

Hänelt I*, #, Wunnicke D*, Müller-Trimbusch M, Vor der Brüggen M, Kraus I, Bakker EP, Steinhoff HJ (2010)
Membrane region M2C2 in subunit KtrB of the K+-uptake system KtrAB from Vibrio alginolyticus forms a flexible gate controlling K+ flux; an electron paramagnetic resonance study.
J Biol Chem 285:28210-28219

Hänelt I#, Löchte S, Sundermann L, Elbers K, Vor der Brüggen M, Bakker EP (2010)
Gain of function mutations in membrane region M2C2 of KtrB open a gate controlling K+ transport by the KtrAB system from Vibrio alginolyticus.
J Biol Chem 285:10318-10327

Kröning N*, Willenborg M, Tholema N, Hänelt I, Schmid R, Bakker EP# (2007)
ATP binding to the KTN/RCK subunit KtrA from the K+-uptake system KtrAB of Vibrio alginolyticus: its role in the formation of the KtrAB complex and its requirement in vivo.
J Biol Chem 282:14018-14027

*equal contribution
#corresponding author

 

 

Contact

Prof. Dr. Inga Hänelt
Biocenter N200/1.08
phone +49-69-798 29 255


Funding