Publications 2026
Rudolph M, Batebi H, Pramod M, Barth K, Hirschberg C, Tampé R, Netz R, Joseph B
Kinetic asymmetry drives directionality in an ATP-binding cassette transporter.
BioRxiv 751009 (2026)
doi:10.64898/2026.09.11.11.751009
Jacobs O, Menche T, Höper C, Gerhards F, Fucek I, Vascotto F, Dietz MS, Heilemann M, Tampé R
Quantitative nanoscale imaging shows peptide-MHC I complexes are monomeric and spatially regulated in human dendritic cells.
Proc Natl Acad Sci USA (2026)
doi:10.1073/pnas.2615838123
Stainer S, Zhu R, Reithofer M, Stadlmayr G, Stadlbauer K, Prangkio P, Rippel C, Hahn M, Kasztner AE, Stohl S, Bednar P, Ruzek D, Glück D, Tampé R, Wozniak-Knopp G, Oh YJ, Klausberger M, Hinterdorfer P
Switching spike plasticity shapes ACE2 engagement across SARS-CoV-2 variants.
Adv Science (2026)
doi:10.1002/advs.77290
Bulankina AV, Richter RM, Nettles JH, Yamane D, Grimm C, Karami Y, Stanton RA, Introini B, Hermann J, Charif H, König MS, Stroß C, Ortiz C, Kraus N, Wood D, Galceran F, Abele R, Maigret B, Schinazi RF, Zeuzem S, Biondi RM, MinKyung Y, Tampé R, Kudryashev M, Welsch C
Phospholipid-driven conformational switching of HCV NS5A links protein folding to replication membrane modeling.
Sci Adv (2026)
doi:10.1126/sciadv.aeb8863
Heinke TJ, Fahim A, Popovic N, Rath T, Morgner N, Trowitzsch S, Tampé R
Reconstitution of glycan-driven MHC I recycling reveals calreticulin as mediator between TAPBPR and tapasin.
Embo J (2026) Front cover story
doi:10.1038/s44318-026-00873-2
Nocker C, Pecak M, Nocker T, Fahim A, Susac L, Tampé R
Single-molecule dynamics reveal ATP binding alone powers substrate translocation by an ABC transporter.
Nat Commun 17, 3038 (2026)
doi:10.1038/s41467-026-70021-1
Stolz M, Susac L, Fahim A, Keller R, Saggau L, Mancia F, Trowitzsch S, Tampé R
Architectural principles of transporter-chaperone coupling within the native MHC I peptide-loading complex.
Science Adv 12, eaea7735 (2026)
doi:10.1126/sciadv.aea7735
Pecak M, Nocker C, Tampé R
ATP-driven conformational dynamics reveal hidden intermediates in a heterodimeric ABC transporter.
eLife 110967 (2026)
doi:10.7554/eLife.110967.2
Bulankina AV, Richter RM, Nettler JH, Yamane D, Grimm C, Karami Y, Stanton RA, Introini V, Hermann J, Charif H, König MS, Stroß C, Ortiz C, Kraus N, Wood D, Abele R, Maigret B, Schinazi RF, Zeuzem S, Biondi RM, Yi M, Tampé R, Kudryashev M, Welsch C
Phospholipid-driven conformational switching of 1 HCV NS5A links protein folding to replication membrane remodeling.
Science Advances, in press (2026)
Schäffner M, Smith CA, Tampé R, Grubmüller H
Braess paradox in enzyme kinetics: Asymmetry from population balance without direct cooperativity.
J Chem Theory Comput, in press (2026)
doi:10.1021/acs.jctc.5c01269
Publications 2025
Stolz M, Susac L, Fahim A, Keller R, Saggau L, Mancia F, Trowitzsch S, Tampé R
US6 hijacks the peptide-loading complex by trapping transport-chaperone dynamics.
Science Adv, accepted, BioRxiv 661491 (2025)
doi:10.1101/2025.06.25.661491
Heinke TJ, Fahim A, Popovic N, Rath T, Morgner N, Trowitzsch S, Tampé R
Reconstitution of glycan-driven MHC I recycling reveals calreticulin as mediator between TAPBPR and tapasin.
BioRxiv 2025.11.25.690393 (2025)
doi:10.1101/2025.11.25.690393
Nocker C, Pecak M, Nocker T, Fahim A, Susac L, Tampé R
Single-molecule dynamics reveal ATP binding alone powers substrate translocation by an ABC transporter.
Nat Commun , accepted, BioRxiv 690960 (2025)
doi:10.1101/2025.11.27.690960
Schäffner M, Smith CA, Tampé R, Grubmüller H
Braess' paradox in enzyme kinetics: asymmetry from population balance without direct cooperativity.
BioRxiv, 2025.07.30.667590 (2025)
doi:10.1101/2025.07.30.667590
Cebrian I, Dinamarca S, Pena Rodriguez MJ, Priego E, Brouwers N, Barends M, Brunnberg J, Tampé R, Blanchard N, Sancho D, Malhotra V
Dendritic cell phagosomes recruit GRASP55 for export of antigen-loaded MHC molecules.
Cell Rep, 44, 115333 (2025)
doi:10.1016/j.celrep.2025.115333
COVER STORYS
