Publications 2018

Atzori A., Malviya, V. N., Malloci, G., Dreier, J., Pos, K. M., Vargiu, A. V., Ruggerone, P. (2018) Identification and characterization of carbapenem binding sites within the RND-transporter AcrB. Biochim Biophys Acta Biomembr. 1861: 62-74.
Pubmed

Pos, K. M. (2018) Bacterial efflux transporters in the limelight. 
Res. Microbiol. 169: 349-350.
Pubmed

Editorial to the Special Issue on Bacterial Efflux Pumps

Du, D., Wang-Kan, X., Neuberger, A., van Veen, H. W., Pos, K. M., Piddock, L. J. V., Luisi, B. F. (2018) Multidrug efflux pumps: structure, function and regulation.
Nat. Rev. Microbiol. 16: 523-539.
Pubmed

Zomot E., Yardeni, E. H., Vargiu, A. V., Tam, H. K., Malloci, G., Ramaswamy, V. K., Perach, M., Ruggerone, P., Pos, K. M., Bibi, E. (2018) A New Critical Conformational Determinant of Multidrug Efflux by an MFS Transporter. J. Mol. Biol. 430: 1368-1385
Pubmed

Tam, H. K.*, Malviya, V. N.*, Pos K. M. (2018) High-resolution crystallographic analysis of AcrB using Designed Ankyrin Repeat Proteins (DARPins) Methods Mol Biol. 1700: 3-24
Pubmed

#equally contributed
*corresponding author

Publications 2017

Lopez, C. A., Travers, T. Pos, K. M., Zgurskaya, H. I., Gnanakaran, S. (2017) Dynamics of intact MexAB-OprM efflux pump: Focusing on the MexA-OprM interface. Scientific Reports 7: 16521
PubMed

Müller, R. T., Travers, T., Cha, H., Phillips, J., Gnanakaran, S., Pos, K. M.* (2017) Switch loop flexibility affects substrate transport of the AcrB efflux pump. J. Mol. Biol. 429: 3863-3874
PubMed 

Gilardi A., Bhamidimarri S. P., Brönstrup M., Bilitewski U., Marreddy R. K. R., Pos K. M., Benier L., Gribbon P., Winterhalter M., Windshügel B. (2017) Biophysical characterization of E. coli TolC interaction with the known blocker hexaamminecobalt. Biochim. Biophys. Acta. 1861: 2702-2709.
PubMed

Masi, M., Réfregiers, M, Pos K. M., Pagès, J-M. (2017) Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria. Nature Microbiol. 2: 17001.
PubMed

Schimo, S.#, Wittig, I.#, Pos, K. M.*, Ludwig, B.* (2017) Cytochrome c oxidase biogenesis and metallochaperone interactions: Steps in the assembly pathway of a bacterial complex. PLoS One 12: e0170037
PubMed

Nöll, A.#, Thomas, C.#, Herbring, V.#, Zollmann, T., Barth, K., Mehdipour, A. R., Tomasiak, T. M., Brüchert, S., Joseph, B., Abele, R., Oliéric, V., Wang, M., Diederichs, K., Hummer, G., Stroud, R. M., Pos, K. M., Tampé, R. (2017) Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP. Proc Natl Acad Sci U S A. 114: E438-E447.
PubMed

#equally contributed
*corresponding author

Publications 2016

Oswald, C.#, Tam, H-K.#, Pos, K. M.* (2016) Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB. Nat. Commun. 7: 13819
PubMed

Vargiu, A. V., Pos, K. M., Poole, K., Nikaido, H. (2016) Bad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative Bacteria. Front Microbiol.7: 833
PubMed

Sjuts H., Vargiu A. V.*, Kwasny S. M., Nguyen S. T., Kim H-S., Ding X., Ornik A. R., Ruggerone P., Bowlin T., Nikaido H*., Pos K. M.*, Opperman T. J.* (2016) Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives. Proc. Nat. Acad. Sci. USA 113: 3509-3514
PubMed

Daury, L., Orange, F., Taveau, J-C., Verechere, A., Monlezun, L., Marreddy, R. K., Picard, M., Broutin, I., Pos, K. M., Lambert, O. (2016) Tripartite assembly of RND multidrug efflux pumps. Nat. Commun. 7: 10731
PubMed

Lytvynenko, I., Brill, S., Oswald, C., Pos, K. M.* (2016) Molecular basis of polyspecificity of the small multidrug resistance efflux pump AbeS from Acinetobacter baumannii J. Mol. Biol. 428: 644-657
PubMed

Hammerschmidt C., Klevenhaus Y., Koenigs A., Hallström T., Fingerle V., Skerka C., Pos K. M., Zipfel P. F., Wallich R., Kraiczy P. (2016) BGA66 and BGA71 facilitate complement resistance of Borrelia bavariensis by inhibiting assembly of the membrane attack complex. Mol Microbiol. 99: 407-424
PubMed

#equally contributed
*corresponding author

Group Members

(For e-mail, just click on the name after "Email")

Dr. Klaas Martinus Pos
Professor & Group Leader     
phone +49-(0)69-798-29251
Email: pos

Ute Imkampe    
Administrative assistant
phone +49-(0)69-798-29238
Email: imkampe

Postdocs

Dr. Reinke Müller
phone: +49-(0)69-798-29241
Email: müller

Dr. Hui Zeng
phone: +49-(0)69-798-29242
Email:zeng

Graduate students

Jessica Kobylka
Phone: +49-(0)69-798-29240
Email: kobylka

Miriam Schmidt
Phone: +49-(0)69-798-29240
Email: schmidt

Maryia Lazarova
Phone: +49-(0)69 - 798 29241
Email: lazarova

Julia Wilhelm    
phone +49-(0)69-798-29241
Email: wilhelm

Technicians

Jasmin El-Delik       
phone +49-(0)69-798-29240
Email: el-delik

Christian Groß
phone: +49-(0)69-798-29236
Email: groß

Andrea Herrmann
phone +49-(0)69-798-29242
Email. herrmann