Publications
Publications 2021
Cuesta Bernal, J., El-Delik, J., Göttig, S., Pos, K. M.* (2021) Characterization and molecular determinants for beta-lactam specificity of the multidrug efflux pump AcrD from Salmonella typhimurium Antibiotics, 10: 1494 Pubmed
Ornik-Cha, A.#, Wilhelm, J.#, Kobylka, J., Sjuts, H., Vargiu, A. V., Malloci, G., Reitz, J., Seybert, A., Frangakis, A. S.*, Pos K. M.* (2021) Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms Nat. Commun. 12:6919
Pubmed
Sumyk, M., Himpich, S., Foong, W. E., Herrmann, A., Pos K. M., Tam, H.K. (2021) Binding of Tetracyclines to Acinetobacter baumannii TetR Involves Two Arginines as Specificity Determinants. Front. Microbiol. 12: 711158. doi: 10.3389/fmicb.2021.711158
Pubmed
Tam. H. K.*, Foong, W. E., Oswald, C., Herrmann, A., Zeng, H., Pos K. M.* (2021) Allosteric drug transport mechanism of multidrug transporter AcrB. Nat. Commun. 12: 3889 doi.org/10.1038/s41467-021-24151-3
Pubmed
Alav, I. , Kobylka, J., Kuth, M. S., Pos, K. M., Picard, M., Blair, J. M. A., Bavro, V. N. (2021). Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria.. Chem. Rev. 121: 5479-5596
Pubmed
Publications 2020
Marine, E.*, Pos, K. M. (2020). Antimicrobial Sensitivity Assay for Bdellovibrio bacteriovorus. Bio-protoc. 10: e3865.
Pubmed
Yousefian, N., Ornik-Cha, A., Poussard, S.#, Decossas, M.#, Berbon, M., Daury, L., Taveau, J. C., Dupuy, J. W., Đorđević-Marquardt, S., Lambert, O*., Pos, K. M.* (2020) Structural characterization of the EmrAB-TolC efflux complex from E. coli. Biochim Biophys Acta Biomembr. 1863: 183488 10.1016/j.bbamem.2020.183488
Pubmed
Marine, E., Millner, D. S., Lambert, C., Sockett, R. E., Pos, K. M.* (2020) A novel method to determine antibiotic sensitivity in Bdellovibrio bacteriovorus reveals a DHFR-dependent natural trimethoprim resistance. Sci. Rep. 10: 5315 10.1038/s41598-020-62014-x
Pubmed
Foong, W. E., Wilhelm, J., Tam, H. K.#, Pos, K. M#*. (2020) Tigecycline efflux in Acinetobacter baumannii is mediated by TetA in synergy with RND-type efflux transporters. J. Antimicrob. Chemother. 10.1093/jac/dkaa015
Pubmed
Tam. H. K., Malviya, V. N., Foong, W. E., Herrmann, A., Malloci G., Ruggerone P., Vargiu A. V.*, Pos K. M.* (2020) Binding and transport of carboxylated drugs by the multidrug transporter AcrB. J. Mol. Biol. 10.1016/j.jmb.2019.12.025
Pubmed
Kobylka, J#., Kuth, M. S.#, Müller, R#. T., Geertsma, E. R., Pos, K. M.* (2020) AcrB: a mean, keen, drug efflux machine. Ann. N. Y. Acad. Sci. 1459: 38-68 10.1111/nyas.14239
Pubmed
Publications 2019
Tietgen, M., Kramer, J. S., Brunst, Djahanschiri, B., Wohra, S., Higgins, P. G., Weidensdorfer, M., Riedel-Christ, S., Pos, K. M., Gonzaga, A. Steglich, M., Nübel, U., Ebersberger, I., Proschak, E., Göttig, S. (2019) Identification of the novel class
D β-lactamase OXA-679 involved in carbapenem resistance in Acinetobacter calcoaceticus. J. Antimicrob. Chemother. dkz080 doi:10.1093/jac/dkz080
Pubmed
Foong, W. E., Tam, H. K., Crames, J. J., Averhoff, B., Pos, K. M.* (2019) The chloramphenicol/H+ antiporter CraA of Acinetobacter baumannii AYE reveals a broad substrate specificity. J. Antimicrob. Chemother. dkz024 doi: 10.1093/jac/dkz024
Pubmed
# = equally contributed
* = corresponding
Group Members
(For e-mail, just click on the name after "Email")
Dr. Klaas Martinus Pos
Professor & Group Leader
phone +49-(0)69-798-29251
Email: pos
Ute Imkampe
Administrative assistant
phone +49-(0)69-798-29238
Email: imkampe
Postdocs
Dr. Reinke Müller
phone: +49-(0)69-798-29241
Email: müller
Dr. Hui Zeng
phone: +49-(0)69-798-29242
Email:zeng
Graduate students
Jessica Kobylka
Phone: +49-(0)69-798-29240
Email: kobylka
Miriam Schmidt
Phone: +49-(0)69-798-29240
Email: schmidt
Maryia Lazarova
Phone: +49-(0)69 - 798 29241
Email: lazarova
Julia Wilhelm
phone +49-(0)69-798-29241
Email: wilhelm
Technicians
Jasmin El-Delik
phone +49-(0)69-798-29240
Email: el-delik
Christian Groß
phone: +49-(0)69-798-29236
Email: groß
Andrea Herrmann
phone +49-(0)69-798-29242
Email. herrmann