Publications 2015

Du, D., van Veen, H.W., Murakami, S., Pos, K. M. And Luisi, B. (2015) Structure, mechanism and cooperation of bacterial multidrug efflux transporters.
Curr. Opinion Struc. Biol. 33: 76-91

Müller R. T., Pos K. M.* (2015) The assembly and disassembly of the AcrAB-TolC three-component multidrug efflux pump.
Biol Chem. 396: 1083-1089

Klingler F. M., Wichelhaus T. A., Frank D., Cuesta-Bernal J., El-Delik J., Müller H. F., Sjuts H., Göttig S., Koenigs A., Pos K. M., Pogoryelov D., Proschak E. (2015) Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria.
J Med Chem. 58: 3626-3630. 

Publications 2014

Ly, K., Bartho, J. D., Eicher, T., Pos, K. M., Mitra, A. K. (2014) A novel packing arrangement of AcrB in the lipid bilayer membrane.
FEBS Lett. 558: 4776-483

Eicher, T., Seeger, M. A.., Anselmi, C., Zhou, W., Brandstätter, L., Verrey, F., Diederichs, K., Faraldo-Gómez, J. D.*, Pos, K. M.* (2014) Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB.
eLife 3: e03145

Cha, H., Müller, R. T., Pos, K. M.* (2014) Switch-loop flexibility affects transport of large drugs by the promiscuous AcrB multidrug efflux transporter.
Antimicrob. Agents Chemother. 58: 4767-4772

Cha, H., Pos K. M* (2014) Cooperative transport mechanism and proton-coupling in the multidrug efflux transporter complex AcrAB-TolC. Membrane Transport Mechanism – 3D structure and beyond. Ed. Krämer, R. and Ziegler, C.
Chapter 9: 207-232.

Publications 2013

Ong, Y. S., Lakatos, A., Becker-Baldus, J., Pos, K. M., Glaubitz, C. (2013) Detecting substrates bound to the secondary multidrug efflux pump EmrE by DNP enhanced solid-state NMR.
J. Am. Chem. Soc., 135: 15754-15762

Hahn, A., Stevanovic, M., Mirus, O., Lytvynenko, I., Pos, K. M., Schleiff, E. (2013) The outer membrane TolC-like channel HgdD is part of tripartite Resistance Nodulation cell Division (RND) efflux systems conferring multiple drug resistance in the cyanobacterium Anabaena sp.
J. Biol. Chem., 288: 31192-31205

Ruggerone, P., Murakami, S., Pos K.M., Vargiu A.V. (2013) RND Efflux Pumps: Structural information translated into function and inhibition mechanisms.
Curr Top Med Chem., 13:3079-3100

Du, D., Venter, H., Pos, K.M., Luisi, B.F. (2013) The Machinery and Mechanism of Multidrug Efflux in Gram-negative Bacteria.
Microbial Efflux Pumps: Current Research. Chapter 3

Publications 2012

Eicher, T., Cha, H., Seeger, M.A., Brandstätter, L., Bohnert, J.A., Kern, W.V., Verrey, F., Grütter, M. G., Diederichs, K., Pos, K. M.* (2012) 
Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop.
Proc. Nat. Acad. Sci USA, 109: 5687-5692

Group Members

(For e-mail, just click on the name after "Email")

Dr. Klaas Martinus Pos
Professor & Group Leader     
phone +49-(0)69-798-29251
Email: pos

Ute Imkampe    
Administrative assistant
phone +49-(0)69-798-29238
Email: imkampe

Postdocs

Dr. Reinke Müller
phone: +49-(0)69-798-29241
Email: müller

Dr. Hui Zeng
phone: +49-(0)69-798-29242
Email:zeng

Graduate students

Jessica Kobylka
Phone: +49-(0)69-798-29240
Email: kobylka

Miriam Schmidt
Phone: +49-(0)69-798-29240
Email: schmidt

Maryia Lazarova
Phone: +49-(0)69 - 798 29241
Email: lazarova

Julia Wilhelm    
phone +49-(0)69-798-29241
Email: wilhelm

Technicians

Jasmin El-Delik       
phone +49-(0)69-798-29240
Email: el-delik

Christian Groß
phone: +49-(0)69-798-29236
Email: groß

Andrea Herrmann
phone +49-(0)69-798-29242
Email. herrmann